Program Outline

8:00 AM  – 8:20 AM
Seating

8:20 AM – 8:30 AM
Introduction by the Chair

Jake Y. Chen, Ph.D.
Founding Director, Systems Pharmacology AI Research Center (SPARC)
Triton Endowed Professor of Biomedical Informatics and Data Science
Adjunct Professor of Genetics, Computer Science, and Biomedical Engineering 
Department of Biomedical Informatics and Data Science
University of Alabama at Birmingham

8:30 AM – 9:30 AM 
Keynote Speech

Alex Zhavoronkov, Ph.D., Founder and CEO at Insilico Medicine, Generative AI in Drug Discovery: case studies of discoveries that progressed into human clinical trials”

9:30 AM  – 9:45 AM
Coffee Break

9:45 AM – 11:00 AM
Research Session

Moderator: Jin Chen, Ph.D., FAMIA
Associate Professor of Medicine, Nephrology, Associate Director for Education, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham

  • Stephen Barnes, Ph.D, Distinguished Professor of Pharmacology and Toxicology, University of Alabama at Birmingham, The plasma pharmacome, EHR and the promise of AI beyond drug discovery. 
  • Aik Choon Tan, Ph.D., Senior Director of Data Science at the Huntsman Cancer Institute, University of Utah, “Computational Strategies for Drug Repurposing and Drug Combination Prediction” 
  • Keshav Singh, Ph.D., Joy and Bill Harbert Endowed Chair and Professor of Genetics, Dermatology and Pathology, University of Alabama at Birmingham, “Baldness to Beauty: Unveiling the Magic of Mitochondria in a Commercial Success”
  • Christopher Willey, M.D., Ph.D., Hale-Stephens ROAR Endowed Professor, Associate Vice Chair for Translational Research in Radiation Oncology, Kinome Core Director, Department of Radiation Oncology, University of Alabama at Birmingham, “Pharmacokinomic Testing in Glioblastoma”

11:00 AM – 12:00 PM
Flash Talk Session

Moderator: Chindo Hicks, Ph.D.

Professor, Department of Genetics, Louisiana State University

  • Rahul Sharma, Ph.D, Informatics Architect, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham, “Enhancing Drug Discovery with “drug-smile-fet”: A User-Friendly Tool for SMILES Feature Extraction” 
  • Brittany Lasseigne, Ph.D, Assistant Professor, Cell, Developmental and Integrative Biology (CDIB), University of Alabama at Birmingham, “Adverse Events are Associated with Sex- and Tissue-biased Drug Target and Metabolism Gene Expression and Gene-regulatory Network Properties 
  • Ehsan Saghapour, Ph.D, Postdoctoral Fellow, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham,From Static to Dynamic: Temporal Visualization of Gene Expression in Cancer Cell Line” 
  • Ilana Chefetz Menaker, Ph.D, Associate Professor, Mercer School of Medicine, Mercer University, “Dual Inhibition of ALDH1A and MEK1/2 Causes Synergistic Cell Death in High-grade Serous Ovarian Cancer Triggered b Enhanced DNA Damage and Diminished DNA Repair” 
  • Kevin Song, Ph.D. student, Biomedical Engineering, University of Alabama at Birmingham, PharmAlchemy: A Comprehensive Knowledge Base for Mining Gene-Drug-Disease Relationships” 

12:00 PM – 1:00 PM
Posters over Lunch

Moderator: Amy Wang, M.D., MBI

Associate Professor of Medicine and Family and Community Medicine, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham

  1.  “Artificial Intelligence in Drug Metabolism Prediction and in Vitro-in Vivo Extrapolations (IVIVE)” , University of Alabama at Birmingham
  2. PharmAlchemy: A Comprehensive Knowledge Base for Mining Gene-Drug-Disease Relationships” , University of Alabama at Birmingham
  3. “Digital Twin of Prec-Clinical Trial: An Advanced Approach for Personalized Oncology Drug Screening”, University of Alabama at Birmingham
  4. “Untargeted Metabolomics Mass Spectroscopy Tools for Data Processing: MS-DIAL, ADAP-BIG, and Asari”, University of Alabama at Birmingham
  5. “Structural Definition of Polyspecific Compensatory Ligand Recognition by P-glycoprotein” , University of Alabama at Birmingham
  6. “BioComputeHub: An On-demand, User Friendly Computation Platform for Biomedical Informatics and Data Science”, University of Alabama at Birmingham
  7. “Exploring SERPINEs as Precision Medicine Biomarkers for Targeted Therapies in Aggressive Prostate Cancer: Insights from Integrated Multi-Omics Pan-Cancer Analysis” , Auburn University
  8. “UAB Biological Data Sciences (U-BDS) core provides comprehensive computational biology support to the UAB research community”, University of Alabama at Birmingham
  9. “Unraveling Endocrinology’s Future: A Comprehensive Exploration of Artificial Intelligence Applications”, Mercer University
  10. “Early Warnings – Leveraging Cell-Painting to Predict Pharmceutical Toxicity”, University of Alabama at Birmingham
  11. “Mondrian Map – Piet Mondrian’s Abstraction for Effective Drug Target Search”, University of Alabama at Birmingham
  12. Unveiling Pancreatic Cancer Gene Interactions: A PAGER Case Study for Drug Discovery Progress“, University of Alabama at Birmingham

1:00 PM – 2:30 PM
Computational Drug Discovery Workshop

Moderator: Lurong Pan, Ph.D.

Senior Scientist, SPARC, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham

  • Teresa Wilborn, PharmD., Ph.D., Professor and Interim Chair, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, “A Guide to Drug Discovery and Development” 
  • Lurong Pan, Ph.D., Senior Scientist, SPARC, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham, “Unleashing the Power of AI in Preclinical Studies: Translational Medicine, Target Modeling, and Drug Design” 
  • Edward Acosta, PharmD., Professor, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, “Navigating Clinical Pharmacology: Pharmacokinetics and Pharmacodynamics in Phase I/II Studies”  
  • Jake Chen, Ph.D., Professor and Chief Bioinformatics Officer, Founding Director SPARC, Department of Biomedical Informatics and Data Science,  University of Alabama at Birmingham “Envisioning the Future: AI’s Transformative Role in Drug Discovery”  

2:30 PM – 2:45 PM
Coffee Break 

2:45 PM – 3:45 PM
Panel Discussion

“AI in Drug Discovery: Hope or Hype?”

Moderator: Jake Y. Chen, Ph.D.,
Professor and Chief Bioinformatics Officer, Founding Director SPARC, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham 

Panelists:

3:45 PM – 5:00 PM
Technical Session

Moderator: Christopher Willey, M.D., Ph.D.

Professor, Department of Radiation Oncology, University of Alabama at Birmingham

  • Bin Chen, Ph.D., Associate Professor of Pediatrics & Human Development, Pharmacology & Toxicology, Michigan State University, “Transcriptomics-based Drug Discovery” 
  • Zhongming Zhao, Ph.D., Chair Professor and Director of Center for Precision Health, University of Texas Health Science Center at Houston (UTHealth), “Deep Generative Neural Network for Accurate Drug Response Prediction” 
  • Amit Mitra, Ph.D., Assistant Professor, Division of Pharmacology, Auburn University, “Drug Discovery Using Omics/Data Science/AI” 
  • Robert Reynolds, Ph.D., Professor, Division of Hematology and Oncology, University of Alabama at Birmingham, “An Overview of Targeted Degradation Technology “

5:00 PM – 5:15 PM
Poster Awards/Closing Remarks

Jake Y. Chen, Ph.D.,
Professor and Chief Bioinformatics Officer, Founding Director SPARC, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham 

Amy Wang, M.D., MBI,
Associate Professor of Medicine and Family and Community Medicine, Department of Biomedical Informatics and Data Science, University of Alabama at Birmingham

5:15 PM – 6:00 PM

Social Networking

Refreshments will be provided